The Changing Face of El Moudjahid During the Algerian War of Independence

The 1956 Soummam conference is considered a turning point for Algeria’s National Liberation Front (FLN), due to a platform that asserted the supremacy of political over military objectives and the corollary importance of diplomacy and public relations. For domestic outreach, the FLN turned to a small publication that had debuted months previously - El Moudjahid - giving it a heightened profile and a new importance. From its founding in June 1956 to the Evian Accords in March 1962, El Moudjahid’s layout evolved dramatically – an evolution most evident on its cover page. The simple style and pamphlet-like shape of the early issues initially shifted to a text-dense “broadsheet” layout, and ultimately by a single photograph. Yet even after the layout stabilized, the page’s various elements continued to evolve. This article argues that these changes illustrate Hayden White’s argument about the “content of the form”: that the physical organization of a page is not inert, but rather influences how readers understand its content. Taking this seriously means turning the analysis from El Moudjahid’s content to its physical structure: its cover page elements and their relationship with the text. Focusing on El Moudjahid’s French edition, this study addresses ten elements: the language used, the presence, size, and placement of the title, authorship, the presence, size, and placement of the crescent and star emblem, the subtitle “Organe Central du Front de Libération Nationale”, inset articles and notices, the presence and location of the place of publication, the amount and currency of the price, the slogan “Révolution Par le Peuple et Pour le Peuple”, and the presence of the Algerian flag. It concludes by examining two time elements: the publication date and the issue number. Complicating Benedict Anderson’s arguments about the linear nature of “national time”, El Moudjahid presented Algeria’s national time as both horizontal and vertical – linear and sacral. Its publication date and issue number anchored the reader in horizontal calendar time. However, as an “organ” El Moudjahid differed from Anderson’s national newspaper. It added verticality by emphasizing the sacrality of anniversaries, like that of November 1, 1954. While scholars have used El Moudjahid as a primary-source archive, they have put little analytic pressure on the cover and other constituent parts. Doing so enables a more substantive understanding of the journal, its operations, and its impact, in ways that can only enrich its archival uses in the future

Part of Imperial Communications: British-Governed Radio in the Middle East, 1934–1949

From 1934 to 1941, three British-governed radio stations were established in the Middle East: Egyptian State Broadcasting (ESB) in Cairo (1934), the Palestine Broadcasting Service (PBS) in Jerusalem (1936), and the Near East Broadcasting Service (NEBS) in Jaffa (1941). These three stations were modeled on the BBC and run as colonial or imperial stations – but they were also considered national stations. As a result, they operated as hybrid entities with overlapping and sometimes conflicting mandates. Through three case studies – a contentious hire at the ESB, the PBS’ “Jerusalem Direct News Service”, and the NEBS’ Islamic broadcasts –, this article charts the evolving relationship between Great Britain and its Arab-world radio stations. Examining these three stations in tandem tension between national and regional broadcasting mandates, as well as the challenge that managing each station raised for British officials in the UK and in-country. It moves away from a focus on the disembodied spheres of ideology and propaganda, and toward the messy administrative decisions that reflected British officials’ on-the-ground efforts to navigate the administrative control and programming decisions in the perplexing world of semi-independent radio broadcasting stations in the Middle East. It closes by noting that while UK-based British officials saw these three stations as operating under the aegis of British governance and on the model of the BBC, the ESB and the PBS, in particular, reflected and projected not a British imperial identity but an Egyptian and a Palestinian nationalist one

Who Heard What When: Learning from Radio Broadcasting Hours and Programs in Jerusalem

Incorporating descriptions and analyses of sound into Middle Eastern history offers a wealth of opportunity for enriching our understanding of the historical record. But sometimes we need to get back to the basics: the “five w\u27s and one h” of sound studies, so to speak. In what follows I would like to run this simple exercise with radio in the Mandate-era Levant, in order to lay out the basic data and begin to reflect on how it might aid scholars in better understanding other aspects of life in this period. I will do this by first addressing some of these basic what, who, when, where, why, how questions, and then by examining one day\u27s programming of the Palestine Broadcasting Service in 1937: the day immediately following the release of the Peel Commission Report. What can we learn from examining this day\u27s programming

Declining Versus Increasing Access to American Aviation Technology: Syria and Saudi Arabia in the 20th Century

This article uses Syria and Saudi Arabia as contrasting examples of how different Arab states interacted with United States aviation technology, involving aviation technology companies, airline cor-porations, and government officials as they worked to develop civil and military aviation capabilities after World War II. It consid-ers the role played by airline companies like TWA, the impact of the shift from military to commercial aviation technology among companies like Boeing, and the fallout from regional political developments like the Iranian Revolution. These factors all placed varying constraints on the two countries’ ability to draw upon American sources for airplanes and other aviation technology, channeling but not preventing Syrian and Saudi efforts toward aviation development. It suggests that the US government acted as gatekeeper in terms of access to US aviation technology, but that unless strategic concerns prompted its involvement, states like Saudi Arabia primarily interacted with US airline and aviation technology corporations

Locating Palestine’s Summer Residence: Mandate Tourism and National Identity

The carving up of the Ottoman Levant into British and French Mandates after World War I introduced new realities for the inhabitants of the region. This article uses Lebanese tourism and the promotion of Lebanon as a tourist destination to Palestinians of all religious backgrounds as a case study to investigate the challenges and potentials of the new Mandate structures. Using Palestinian government archives and newspapers, it examines how Lebanon was marketed to Palestinian vacationers. It concludes by suggesting that tourism, with its mixture of private and government sector interests, serves as a key node for observing the messy process of relational identities when two sets of neighbors worked to reframe themselves in national terms

Syria and the Olympics: National Identity on an International Stage

Since its 1946 independence, Syria has fielded a team for every summer Olympic competition except 1956, yet has won only three Olympic medals. In contrast with its smaller, higher-powered neighbor Lebanon, its participation at the Olympics has been consistent but limited, with the country making little impact internationally. Yet the history of Syria’s involvement with the Olympics reflects key elements of its political and social history: its ambitious but short-lived partnership with Egypt, the Baathist-supported promotion of women as athletes and head of the National Olympic Committee, and its commitment to participation in the vexed but ideologically important Pan-Arab Games. This article uses official International Olympic Committee publications and related press coverage to examine the history of Syria’s involvement with the Olympic Games, the Mediterranean Games, and the Pan-Arab Games. It argues that Syria’s participation was initially important not for its medal count but for the “sign of statehood” that membership in the Olympic community conferred, and that its participation in regional games supported Syria’s political positions as a Baathist, Arab republic. It concludes by contending that these political commitments have renewed salience as the conflict in Syria that began in March 2011 continues, and the country’s participation in Olympic and regional games becomes increasingly politicized

High-fat diet alters stress behavior, inflammatory parameters and gut microbiota in Tg APP mice in a sex-specific manner

Long-term high-fat diet (HFD) consumption commonly leads to obesity, a major health concern of western societies and a risk factor for Alzheimer's disease (AD). Both conditions present glial activation and inflammation and show sex differences in their incidence, clinical manifestation, and disease course. HFD intake has an important impact on gut microbiota, the bacteria present in the gut, and microbiota dysbiosis is associated with inflammation and certain mental disorders such as anxiety. In this study, we have analyzed the effects of a prolonged (18 weeks, starting at 7 months of age) HFD on male and female mice, both wild type (WT) and TgAPP mice, a model for AD, investigating the behavioral profile, gut microbiota composition and inflammatory/phagocytosis-related gene expression in hippocampus. In the open-field test, no overt differences in motor activity were observed between male and female or WT and TgAPP mice on a low-fat diet (LFD). However, HFD induced anxiety, as judged by decreased motor activity and increased time in the margins in the open-field, and a trend towards increased immobility time in the tail suspension test, with increased defecation. Intriguingly, female TgAPP mice on HFD showed less immobility and defecation compared to female WT mice on HFD. HFD induced dysbiosis of gut microbiota, resulting in reduced microbiota diversity and abundance compared with LFD fed mice, with some significant differences due to sex and little effect of genotype. Gene expression of pro-inflammatory/phagocytic markers in the hippocampus were not different between male and female WT mice, and in TgAPP mice of both sexes, some cytokines (IL-6 and IFN¿) were higher than in WT mice on LFD, more so in female TgAPP (IL-6). HFD induced few alterations in mRNA expression of inflammatory/phagocytosis-related genes in male mice, whether WT (IL-1ß, MHCII), or TgAPP (IL-6). However, in female TgAPP, altered gene expression returned towards control levels following prolonged HFD (IL-6, IL-12ß, TNF¿, CD36, IRAK4, PYRY6). In summary, we demonstrate that HFD induces anxiogenic symptoms, marked alterations in gut microbiota, and increased expression of inflammatory genes, except for female TgAPP that appear to be resistant to the diet effects. Lifestyle interventions should be introduced to prevent AD onset or exacerbation by reducing inflammation and its associated symptoms; however, our results suggest that the eventual goal of developing prevention and treatment strategies should take sex into consideration.This work was supported by Ministerio de Economía, Industria y Competitividad (MINECO), Grant Numbers BFU2014-51836-C2-1-R to LMGS and MAA, BFU2014-51836-C2-2-R and BFU2017-82565-C21-R2 to JAC; Madrid Council S2010/BMD-2349 to MLC; Centre for Biomedical Network Research for Physiopathology of Obesity and Nutrition (CIBEROBN) to JAC, Centre for Biomedical Network Research for Frailty and Healthy Ageing (CIBERFES) to LMGS and MAA, and Centre for Biomedical Network Research for Neurodegenerative Diseases (CIBERNED) to MLC. AC-C was granted with a FPI fellowship by the MINECO (BES-2015-072980)

Design and manufacture of a novel system to simulate the biomechanics of basic and pitching shoulder motion

Objectives Cadaveric models of the shoulder evaluate discrete motion segments using the glenohumeral joint in isolation over a defined trajectory. The aim of this study was to design, manufacture and validate a robotic system to accurately create three-dimensional movement of the upper body and capture it using high-speed motion cameras. Methods In particular, we intended to use the robotic system to simulate the normal throwing motion in an intact cadaver. The robotic system consists of a lower frame (to move the torso) and an upper frame (to move an arm) using seven actuators. The actuators accurately reproduced planned trajectories. The marker setup used for motion capture was able to determine the six degrees of freedom of all involved joints during the planned motion of the end effector. Results The testing system demonstrated high precision and accuracy based on the expected versus observed displacements of individual axes. The maximum coefficient of variation for displacement of unloaded axes was less than 0.5% for all axes. The expected and observed actual displacements had a high level of correlation with coefficients of determination of 1.0 for all axes. Conclusions Given that this system can accurately simulate and track simple and complex motion, there is a new opportunity to study kinematics of the shoulder under normal and pathological conditions in a cadaveric shoulder model.</br

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts